Introduction
This report explains how GLP‑1 and GLP‑1/GIP weight‑loss medications cause significant fat loss but can also lead to notable reductions in lean mass, including muscle and bone. It highlights the heightened risk for older adults and those with certain health conditions. Exercise—especially resistance training—and adequate protein intake are essential to minimise muscle loss and support long‑term weight management. The report calls for stronger collaboration between healthcare and the fitness sector, improved training for professionals, and further research to define optimal exercise protocols.
